Journal of Allergy and Clinical Immunology
Off-Treatment Efficacy of Barzolvolimab in Chronic Spontaneous Urticaria
Chaudhry U, Metz M, Anderson J, et al
This analysis reports post-treatment outcomes from a phase 2 clinical trial evaluating barzolvolimab (an anti-KIT monoclonal antibody) in patients with antihistamine-refractory chronic spontaneous urticaria, specifically assessing durability of response after treatment discontinuation. Barzolvolimab produced sustained clinical benefits, with a substantial proportion of patients maintaining complete disease control months after the last dose, indicating prolonged off-treatment efficacy. The treatment was also well tolerated, supporting its potential as a disease-modifying therapy rather than one requiring continuous administration.
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