Journal of Allergy and Clinical Immunology
Navenibart Delays Time to First HAE Attack
Tachdjian R, Riedl M, Li H, et al
The Phase 1b/2 ALPHA-STAR trial evaluated the safety, efficacy, and time to first attack after treatment with the long-acting anti–plasma kallikrein monoclonal antibody navenibart in patients with hereditary angioedema. Navenibart markedly reduced attack rates and substantially prolonged the time to first HAE attack, with many patients remaining attack-free for extended periods. The treatment was well tolerated and supports further development of infrequent dosing regimens in Phase 3 studies.
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