David A. Fisher, MD, director, Total Joint CenterIndiana Orthopaedic Hospital discusses which patients qualify as candidates for total knee replacement surgery. According to Fisher, progressive loss of function that impacts quality of life, along with significant x-ray changes will often qualify a patient for the operation, provided they are in good health and have been screened by an internist. Potential risks of knee replacement surgery include deep venous thrombosis, infection or anesthesia-related conditions. Resources & Referenceswww.indianaorthopaedichospital.com/bio-cards/Fisher.pdfwww.ncbi.nlm.nih.gov/pubmed/22868835www.depuysynthes.com/patients/knee/attune-knee Disclosures: David A. Fisher, MD Royalty: DePuy Synthes Patent Holder: DePuy Synthes Speaker’s Bureau: DePuy Synthes