Margot Putukian, MD, Chief Medical Officer of Major League Soccer; Christina L. Master, MD, Professor of Clinical Pediatrics at the University of Pennsylvania Perelman School of Medicine; and Siobhan Statuta, MD, sports medicine primary care specialist, University of Virginia School of Medicine, discuss concussion, returning to play, and a sports mental health assessment. They also discuss the risks of continued exertion for athletes, evidence-based factors with athlete risk tolerance, and the effects of exercise on disease/illness.