Robert Kirsner, MD, PhD, University of Miami, Florida; Oscar M. Alvarez, PhD, Rutgers New Jersey Medical School, Newark, New Jersey; Vickie R. Driver, DPM, MS, INOVA Health System, Alexandria, Virginia; and Bill Marston, MD, University of North Carolina School of Medicine, Cherry Hill, North Carolina, discuss the reliability and transferability of current randomized controlled trials (RCTs) based on real-world evidence. The discussants covered how to define, compare, and contrast RCTs; how to design prospective studies, recruit, and manage patients; and how to investigate how reliable and transferable RCTs are in wound care therapies.