Chetan Deshmukh, MBBS, a medical oncologist from Deenanath Mangeshkar Hospital and Research Center, Pune, India, discusses the CAIRO5 study, which was presented at the congress, and shares his thoughts on novel immunotherapeutics and targeted therapies for the management of colorectal cancer. Dr Deshmukh also comments on how patients can gain access to novel treatments in global clinical trials and he provides thoughts on drug access disparities in low- and middle-income countries.