Lea Grinberg, MD, PhD, Professor of Neurology at the University of California San Francisco Weill Institute for Neurosciences and Memory and Aging Center, shares insights into recent research on the relevance of tau post-translational modifications for Alzheimer's disease pathology. While most studies only look at tau phosphorylation, Dr. Grinberg's findings show caspase-6 cleavage of tau leaves a truncated version of tau prone to toxic aggregation in the human brain, and in many cases truncated tau was not phosphorylated. Dr. Grinberg concludes examining tau phosphorylation alone may not accurately measure Alzheimer's disease or other tau-related pathologies.