This video explores the treatment of chronic myeloid leukemia (CML) in special populations. Dr. Mari Copland from the University of Glasgow covers considerations for managing CML in patients with comorbidities, intolerances, and in those with high-risk chronic or blast phases. Key points include treatment guidelines, response monitoring, and addressing TKI resistance. The presentation also touches on managing CML during pregnancy, emphasizing the balance between treatment efficacy and patient safety. Strategies for post-transplant care and handling complex cases, including those with drug resistance or secondary conditions, are also discussed.