Miguel Materin, MD, Director of Ocular Oncology Section, Yale Eye Center, discusses chromosomal analysis within a tumor, the most important guide to clinical survival.
Summary:
Chromosal analysis of uveal melanoma can be performed and can give accurate predictions of clinical survival.
References and Resources:
Trolet J, Hupé P, Huon I, Lebigot I, Decraene C, Delattre O, Sastre-Garau X, Saule S, Thiéry JP, Plancher C, Asselain B, Desjardins L, Mariani P, Piperno-Neumann S, Barillot E, Couturier J. Genomic profiling and identification of high-risk uveal melanoma by array CGH analysis of primary tumors and liver metastases. Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2572-80. Epub 2009 Jan 17.
Shields CL, Ganguly A, Materin MA, Teixeira L, Mashayekhi A, Swanson LA, Marr BP, Shields JA. Chromosome 3 analysis of uveal melanoma using fine-needle aspiration biopsy at the time of plaque radiotherapy in 140 consecutive cases. Trans Am Ophthalmol Soc. 2007;105:43-52; discussion 52-3.
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