This video discusses IgA nephropathy (IgAN), a kidney disease where proteins from the immune system build up in the kidney filters, causing inflammation and potential damage. It details how IgAN can lead to chronic kidney disease or failure if untreated, and outlines the symptoms such as blood or foam in urine, fatigue, back pain, swelling, and high blood pressure. Diagnosis typically involves a biopsy. Treatment options include medication, dietary changes, and lifestyle adjustments, emphasizing the importance of mental health support.