James Januzzi, MD, explores the use of cardiac biomarkers like natriuretic peptides and troponin in heart failure management. He discusses their evolution from diagnostic tools to predictors of future cardiovascular issues and their role in guiding treatments to improve patient outcomes. Januzzi emphasizes a shift towards preventive cardiology, using these markers to detect heart disease early. He also introduces the potential of omics technologies in enhancing personalized medicine, paving the way for more targeted and effective heart disease management.