Valentin Fuster, MD, PhD, MACC, chairs this annual post-ACC meeting roundtable summarizing cutting-edge cardiovascular research. Joined by experts Clyde Yancy, MD, MSc; Julia Indik, MD, PhD; Vinod Thourani, MD; and Rasha Al-Lamee, MD, they discuss pivotal studies from the American College of Cardiology sessions. Topics include trials on heart failure interventions, hypertrophic cardiomyopathy treatments, hypertension innovations, and PCI in vulnerable plaques. While several studies highlighted challenges, promising advances like subcutaneous hypertension therapies inspired optimism. The panel emphasizes interdisciplinary collaboration and ongoing scientific exploration to address unmet needs in cardiovascular care.