Using a multivariate regression analysis, it has been shown that people with a common genetic mutation have up to twice the risk of lung cancer as do people without the variation.

References and Resources
Yang P, Sun Z, Krowka M, et al. Alpha1-Antitrypsin Deficiency Carriers, Tobacco Smoke, Chronic Obstructive Pulmonary Disease, and Lung Cancer Risk. Arch Intern Med 2008; 168(10): 1097-1103.

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