Cassandra Calabrese, DO, Cleveland Clinic, Cleveland, Ohio, and Samantha Polly, MD, Duke University School of Medicine, Durham, North Carolina, discuss immunizations in patients with immune-mediated inflammatory diseases and immunocompromised individuals in the era of COVID-19. Dr Calabrese provided highlights and updates related to influenza, pneumococcal disease, herpes zoster, and SARS-CoV-2. Dr Polly discussed adjunct therapies to optimize response to targeted immunologic treatments.