Careers  |  Sign In  |  Register

Cancer and Melanoma

Mutations and B-Raf protein

David B. Solit, MD, Elizabeth and Felix Rohatyn Chair for Junior Faculty, Memorial Sloan-Kettering Cancer Center, discusses B-Raf, an intracellular signaling protein.B-Raf is commonly mutated in cancer, and about 8% of all human cancers have B-Raf mutation. This in turn makes the cells grow abnormally and it is most commonly found in melanoma. There are now companies trying to develop inhibitors of B-Raf.

Apoptosis of human melanoma cells induced by inhibition of B-RAF(V600E) involves preferential splicing of bim(S).
Jiang CC, Lai F, Tay KH, Croft A, Rizos H, Becker TM, Yang F, Liu H, Thorne RF, Hersey P, Zhang XD.
Cell Death Dis. 2010 Sep 2;1(9):e69.