Forest W. Arnold, DO, MSc, FIDSA, interim chief and associate professor, Division of Infectious Diseases, University of Louisville, discusses co-infections in COVID-19, focusing on case reports, pathophysiology, etiology, frequency, diagnosis, and treatment. According to Dr Arnold, COVID-19 may be associated with a co-infection, but not as commonly as once was thought. Some co-infections may be hospital-acquired superinfections that require prevention measures and early treatment. Dr Arnold explained that procalcitonin may be a tool that can supplement patient history and physical exam.