Lena Edwards, MD, internist, Balance Health & Wellness Center, discusses stress and anxiety. Depression and anxiety are directly linked to HPA (hypothalamic-pituitary-adrenal axis) and increase in cortisol. SSRIs improve glucocorticoid receptor sensitivity. It is important for doctors to measure and identify abnormal cortisol release states in their patients.
Interaction of Serotonin Transporter Gene-Linked Polymorphic Region and Stressful Life Events Predicts Cortisol Stress Response.
Mueller A, Armbruster D, Moser DA, Canli T, Lesch KP, Brocke B, Kirschbaum C.Neuropsychopharmacology. 2011 Mar 2.