At the ENDO 2022 press conference, the clinical practice guideline on management of hyperglycemia in hospitalized patients in non-critical care settings was presented by Mary Korytkowski, MD, University of Pittsburgh, Pittsburgh, PA; Y.M. Melody Cheung, MD, PhD, Brigham and Women’s Hospital, Boston, MA; Claire Lee, BS (medical student), and Geethika Thota, MBBS, St Peter’s Healthcare System, New Brunswick, NJ. They also discussed the importance of early recognition of prediabetes and the need for interventions to prevent cardiovascular complications.