Bryan Eckerle, MD, MSc, Vascular Neurologist and Neurohospitalist, Norton Healthcare, Louisville, Kentucky, discusses stroke mimics and chameleons. Stroke mimics are neurological presentations with symptoms that can be mistaken for acute stroke, and are identified in up to 25% of stroke referrals. According to Dr Eckerle, being aware of stroke mimics and acumen in distinguishing them from acute stroke may reduce the reliance on advanced imaging prior to IV t-PA administration, resulting in faster diagnosis and appropriate treatment.