The RCC Content Hub Channel
David Simel, MD, and William Kim, MD, explore renal cell carcinoma in this JAMA Clinical Review podcast. They discuss key insights from the 2019 Nobel Prize research on VHL mutations and HIF-alpha, linking tumor growth and angiogenesis. Advances in diagnostics, such as renal mass protocols and the Bosniak classification for cystic tumors, were highlighted. Treatment options for localized and metastatic disease, including nephrectomy, VEGF inhibitors, and immunotherapy, demonstrate the impact of molecular biology on care. Surveillance protocols and survival rates are examined, emphasizing progress in managing this malignancy.