Carol M. Mangione, MD, MSPH, FACP, Chief of the Division of General Medicine & Health Services Research and Professor of Medicine and Public Health at UCLA, discusses the biggest challenges clinicians face when caring for older adults with diabetes. Many older adults have comorbidities that may not be directly related to diabetes. Geriatric syndromes, including gait problems, depression, chronic pain, and challenges with polypharmacy should also be considered.