Bartolome Burguera, MD, PhD, describes the Endocrinology and Metabolism Institute, which is part of Cleveland Clinic. This multidisciplinary institute includes more than 50 medical and surgical endocrine specialists, pituitary specialists, pharmacists, exercise physiologists, dietitians and nurses along with a team of medical assistants, diabetes care and education specialists, secretaries, patient service representatives, coders, administrators and managers. They focus on targeting weight to improve health. Marcio Griebeler, MD, director of the Diabesity Center, describes how the complexity of obesity underscores the need for multidisciplinary care.