Brian G. M. Durie, MD, chairman of the board of the International Myeloma Foundation, discusses whether patients with borderline high-risk smoldering myeloma should begin treatment early. Some treatments can be helpful for patients with high-risk smoldering myeloma, with early treatment leading to long-term remission and prolonged survival. Dr. Durie indicates that myeloma levels should be monitored closely and options should be considered carefully to determine whether treatment is necessary.