Maryam Rahman, MD, MS, an assistant professor in the Department of Neurosurgery and the UF Brain Tumor Immunotherapy Program at the University of Florida, discusses diagnostic and therapeutic considerations for patients with glioblastoma. She covers risk factors, pathology, RANO criteria, and standard treatment for patients with glioblastoma. Glioblastoma is characterized by necrosis and other molecular features. The standard treatment is 60 Gy radiotherapy, and concomitant and adjuvant temozolomide and tumor-treating fields. Modified RANO criteria are used to follow lesions over time.