Vito Sabato, MD, PhD, allergist, University of Antwerp, Belgium; Prithviraj Bose, MD, hemato-oncologist, MD Anderson Cancer Center, University of Texas, USA; and Sigurd Broesby-Olsen, MD, dermatologist, Odense University Hospital, Odense, Denmark, provide insights related to the diagnosis of systemic mastocytosis. They also discuss current and emerging therapeutic options for patients and strategies for improving multidisciplinary patient care.