In a meeting of the Advisory Committee on Immunization Practices in March 2023, the focus was on the respiratory disease surge in Fall 2022 in the United States, with presentations from Lisa Grohskopf, Samantha Olson, Nathaniel Lewis, Mark Tenforde, CDC/NCIRD, and Huong McLean, Marshfield Clinic Research Institute. These experts provided an update on US influenza activity. They also discussed preliminary 2022-23 influenza vaccine effectiveness and published estimates of live attenuated vaccine effectiveness.