At the 2022 ESMO Florida conference, Mariana Chavez-MacGregor, MD, MSc, associate professor, Department of Breast Medical Oncology and Department of Health Services Research, University of Texas MD Anderson Cancer Center, Houston, Texas, provides insight on factors to consider related to staging and assessment of recurrence risk in patients with early breast cancer. Dr Chavez-MacGregor believes that, in the future, more biological factors will be considered and the staging system will be simplified. According to Dr Chavez-MacGregor, biology matters a lot for prognosis and treatment.