Rosenberg AS, Brunson A, Tuscano J, et al. Effect of autologous hematopoietic stem cell transplant on the development of second primary malignancies in multiple myeloma patients. Blood Cancer J. 2021;11(1):5.
Autologous Stem Cell Transplant Can Increase Development of Second Primary Malignancies in Multiple Myeloma
In a study of 16,331 patients in the California Cancer Registry, 5.7% developed a second primary malignancy more than 1 year after diagnosis. The 10-year cumulative incidence of developing any second primary malignancy was similar among patients who did and did not receive autologous stem cell transplant. The 10-year cumulative incidence of hematologic second primary malignancies was higher among autologous stem cell transplant recipients; however, mortality was driven by multiple myeloma and non-cancer causes.
