This study shows that compared with activation in the MTL, deactivation in the PMCs could be a more sensitive marker of early AD at functional MR imaging.

References and Resources
Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging.
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Alexander Drzezga, Nicola Lautenschlager, Hartwig Siebner, et al., Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer’s disease: a PET follow-up study. European Journal of Nuclear Medicine and Molecular Imaging. Volume 30, Number 8.
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