Curr Treat Options Oncol
Updates on Therapy Options in Fit and Unfit Patients with Newly Diagnosed AML
Magee GH, Grunwald MR
In this review article, the authors discussed how the integration of next-generation sequencing and advanced cytogenetic diagnostics into routine clinical practice is reshaping frontline treatment in both fit and unfit patients with acute myeloid leukemia. With the continued evolution of the therapeutic landscape for acute myeloid leukemia continues to evolve, timely molecular characterization is essential for optimizing outcomes and choosing the most appropriate frontline strategy.
- • Treatment patterns and survival outcomes for very elderly patients with acute myeloid leukemia: A National Cancer Database study
- • Updates on Therapy Options in Fit and Unfit Patients with Newly Diagnosed AML
- • Quality of life and life satisfaction in long-term survivors of acute myeloid leukemia
- • Integrative genomic and immune profiling to identify and characterize high-risk subgroups in AML: development of a 20-gene predictive signature
- • Targeting p16INK4a-mediated cellular senescence as a therapeutic strategy for FLT3-ITD-driven AML
- • Gilteritinib in FLT3-mutated AML: a real-world Italian experience
- • Decitabine combined with reduced-intensity conditioning for older patients with AML in composite complete remission undergoing allogeneic hematopoietic stem cell transplantation
- • Prognostic covariates associated with outcomes in patients with NPM1-mutated AML
- • Venetoclax combined with azacitidine in elderly AML
- • Dose escalation study of the HLA-A2-WT1 CD3 bispecific antibody RO7283420 in relapsed/refractory AML
- • Phase I first-in-human dose escalation study of the oral casein kinase 1α and cyclin dependent kinase 7/9 inhibitor BTX A51 in advanced MDS and AML
- • Bexmarilimab plus azacitidine for high-risk MDS and relapsed or refractory AML
- • Comparison of consolidation strategies for pediatric patients with AML
- • Molecular monitoring versus standard clinical care in younger adults with AML
- • A phase 2 trial of geriatric assessment-guided selection of treatment intensity in older adults with AML