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Studies question value of biomarkers, including CRP, for predicting heart disease

Reuters Health • The Doctor's Channel Daily Newscast

2:02  |   Posted on Jul 1, 2009 in Cardiology, Critical Care, Emergency Medicine, Family Medicine, Internal Medicine, Pathology & Lab Medicine, Reuters Health • The Doctor's Channel Daily Newscast

NEW YORK (Reuters Health) – C-reactive protein (CRP) does not appear to have a causal role in coronary heart disease (CHD), and using it to predict the risk of cardiovascular events offers little added benefit over use of conventional risk factors, according to two studies in the July 1 issue of the Journal of the American Medical Association.

In the first study, Dr. Paul Elliott of Imperial College London, and colleagues performed a genome-wide association (n = 17,967) and replication study (n = 13,615) to identify genetic loci associated with plasma CRP levels.

The analysis, Dr. Elliott and colleagues report,

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