Treat-to-target recommendations for rheumatoid arthritis (RA) emphasize the need for early therapeutic intervention using disease-modifying antirheumatic drugs, with the goal of disease remission. However, diagnosis and active therapy for early RA is often delayed, which can have long-term adverse consequences on disease progression. By providing evidence-based “top 10” pearls to primary care physicians (PCPs), rheumatologists can help them to diagnose RA and to be familiar with the available treatment options for RA. Chronotherapeutic advances in the treatment of RA can help PCPs to bridge therapy while awaiting a specialist appointment. Chronotherapy–defined as the judicious timing of conventional or special drug-release therapeutic interventions in order to align drug peak and trough concentrations to specific circadian rhythm markers of disease activity–is a means to optimize treatment outcomes and potentially minimize adverse effects.