Xavier Pi-Sunyer, MD, MPH, discusses incretin therapy, a treatment which increases insulin secretion in type 2 diabetes patients. According to Pi-Sunyer, GLP-1 can be raised in the blood stream in two ways, effectively increasing insulin secretion. The first method involves inhibiting the enzyme that destroys it, while the second focuses on altering the molecule to hit the receptor and act as a GLP-1 receptor agonist, lasting much longer in the bloodstream due to its modification.