An open randomized trial showed that for a first episode of schizophrenia, four second-generation antipsychotics were no more effective than haloperidol, but they did have lower discontinuation rates.

References and Resources Kahn R, Fishbaker W, Botter H, et al. Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial. The Lancet 2008; 371:1085-1097.

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