Abigail Schubach, MD, Gary S. Firestein, MD, and  Ellen M. Gravallese, MD discuss the complexities of Rheumatoid Arthritis (RA), an autoimmune condition affecting millions globally. These doctors talk about the pathogenesis of RA, distinguishing between seropositive and seronegative types and their implications for treatment. They cover diagnostic criteria, including the importance of early detection for managing symptoms and preventing severe joint damage. Innovations in RA treatment, such as DMARDs and targeted therapies, are discussed, highlighting the shift towards personalized medical approaches to enhance patient outcomes and potentially prevent the disease.