Jordi Díaz-Manera, MD, PhD, a Professor of Neuromuscular Disorders from the John Walton Muscular Dystrophy Research Centre at Newcastle University, discusses Pompe disease and the use of MRI in diagnosis and follow-up. Muscle MRI using T1w imaging can be used to identify a pattern of fatty replacement that is useful for diagnosis. According to Dr Díaz-Manera, fat replacement on MRI is a good biomarker that correlates with muscle function.