In this IDF Forum, Roger Kobayashi, MD, and Laura Rohe, RN, from Asthma, Allergy, and Immunology Associates, discuss primary immunodeficiency and the importance of monitoring patients. Most patients and health care providers underestimate or may be unaware of the potential consequences resulting from careless or improper patient monitoring. It is possible for patients with immune deficiency to be unaware that they have a disease with potential severe complications. Dr Kobayashi emphasizes the need to know about your disease and what can go wrong.