Targeted Approaches to Systemic Mastocytosis Management
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Matthew Giannetti, MD, Harvard Medical School, and Anne Maitland, MD, PhD, Mount Sinai, discuss nonadvanced systemic mastocytosis. They review pathophysiologic processes in systemic mastocytosis, with a focus on clinical manifestations and rationale for new targeted therapies. They also discuss evaluation of patients to characterize symptoms, disease burden, and results from testing. Finally they discuss clinical trial evidence and how to individualize treatment regimens for patients.