Host Timothy Murray, MD, Murray Ocular Oncology and Retina, Miami, Florida, and Katherine E. Talcott, MD, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, discuss the clinical implications of treatment lapses in patients with diabetic macular edema and the importance of identifying individuals who have increased risk for vision loss. Dr Talcott also describes predictors of vision loss, including longer lapses, diabetic foot disease, and Medicaid insurance. Dr Talcott also notes how these insights may help improve patient counseling, guide personalized care, and support interventions to preserve vision in these patients.