The Oncology / Hematology Channel
09:35 | Oncology / Hematology
James Edwards explains Paroxysmal Nocturnal Hemoglobinuria (PNH), a rare blood disorder caused by a mutation in the PIGA gene, which affects the GPI anchor proteins that protect red blood cells. Without these proteins, red blood cells are vulnerable to destruction by the complement system, leading to hemolysis, thrombosis, and dark urine. Key topics include the role of protective proteins (CD55, CD59), clinical symptoms, and treatments such as complement inhibitors and stem cell transplants. The video emphasizes PNH’s impact on red blood cell health and potential life-threatening complications.