Gisela Wilcox, BMedSc, MBBS, MD, consultant in metabolic medicine, Salford Royal NHS Foundation Trust, discusses body composition, how Pompe impacts nutritional status, and the role of nutritional interventions in Pompe disease. Dr Wilcox highlights the need to correct micronutrient deficiencies to avoid further worsening of functional deficits, and the need to ensure adequate calorie and nutrient intake for maintenance. She also discusses the potential influence of Pompe disease on COVID-19 risk and provides tips for staying well in this current situation.