Hana Niebur, MD, assistant professor at the University of Nebraska Children’s Hospital and Medical Center, discusses non-infectious complications of primary immune deficiency. Lung disease is the most common non-infectious manifestation, affecting up to 70% of patients with primary immunodeficiency. Gastrointestinal disease occurs in up to 50% of patients with primary immunodeficiency. Dr. Niebur also indicates that patients may experience autoimmune conditions, including arthritis, cytopenias, dermatologic disease, and endocrinopathies. She also highlighted the importance of regular screening to increase the chance of early diagnosis.