Today there are more highly effective treatments for patients with HIV. However, these patients can also have higher rates of hepatitis C infection. Even though the HIV is well controlled, patients can still become very ill and, in some cases, even die from liver disease related to hepatitis C. A new study tested whether an interferon-free medication regimen would be effective in patients who have both HIV and hepatitis C infection. Catherine Dolf explains in this week’s JAMA Report.