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Modified Flu Virus May Offer Safer Vaccination for Immunocompromised Patients

Vaccines are weakened versions of viruses that, when introduced into the body, allow the immune system to easily build up antibodies to a particular virus without actually becoming infected. However, some patients suffer from a weakened immune system and can be put under pressure when given vaccines. New research is focusing on developing an influenza vaccine that is a live version of the virus, but with an essential amino acid removed, rendering it unable to infect its host, but still inducing the antibody-building immune response desired when administering a traditional vaccine.

Click here to read more about this research in Science Daily.


Longlong S, H Xu, X Zhou, Z Zhang, et al. Generation of influenza A viruses as live but replication-incompetent virus vaccines. Science. 2016. DOI:10.1126/science.aah5869

Timmer J. Virus engineered to rely on artificial amino acids, used as vaccine. Arstechnica UK website. Published online December 2, 2016.