Jay S. Duker, MD, Director of the New England Eye Center, discusses the characteristics and complications of age-related macular degeneration as well as the evolution of treatments for AMD, including the development of anti-VEGF therapies in the last 6 years. Disclosures: Consulting Fees: Novartis, QLT, EMD Serono, ThromboGenics, Optos Contracted Research: Carl Zeiss Meditec, Optovue Ownership Interest: EyeNetra, Hemera, Ophthotech, Paloma