Dana V. Rizk, MD, professor of medicine, University of Alabama at Birmingham; and Gerald Appel, MD, professor of medicine and co-director of the Center for Glomerular Disease, Columbia University Irving Medical Center, New York, New York, discuss advancements in IgA nephropathy. They discuss the pathophysiology of IgA nephropathy, guideline- and trial-based strategies for managing patients with IgA nephropathy, and guidance for incorporating emerging therapies into the current IgA nephropathy treatment armamentarium.