Robert Goldberg, MD, Chief, Orbital and Opthalmic Plastic Surgery, David Geffen School of Medicine UCLA, discusses new advances on the medical and surgical sides of Graves’ Eye Disease, and in particular, the IGF antibody and its relationship to TSH.

Reading:
Matos K, Manso PG, Marback E, Furlanetto R, Alberti GN, Nosé V. Protein expression of VEGF, IGF-1 and FGF in retroocular connective tissues and clinical correlation in Graves’ ophthalmopathy. Arq Bras Oftalmol. 2008 Jul-Aug;71(4):486-92.
Tsui S, Naik V, Hoa N, Hwang CJ, Afifiyan NF, Sinha Hikim A, Gianoukakis AG, Douglas RS, Smith TJ. Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves’ disease. J Immunol. 2008 Sep 15;181(6):4397-405.
Khoo TK, Bahn RS. Pathogenesis of Graves’ ophthalmopathy: the role of autoantibodies. Thyroid. 2007 Oct;17(10):1013-8. Review.