Specialists in pediatric infectious disease from New York-Presbyterian Morgan Stanley Children’s Hospital and Columbia University Irving Medical Center, including Candace Johnson, MD, assistant professor of pediatrics; Lisa Saiman, MD, professor of pediatrics; Jason Zucker, MD, assistant professor of medicine; and Natalie Neu, MD, professor of pediatrics, discuss emerging and re-emerging infectious diseases in children and adolescents in 2022. The panelists cover topics such as COVID-19, enterovirus D68, human monkeypox virus, influenza, vaccines, and RSV. They also review the role of health care providers in diagnosis and management of these diseases.