Allan Klompas, MBBCh, BAO, an assistant professor of anesthesiology and physician in the Department of Anesthesiology at Mayo Clinic, discusses transfusion support of extracorporeal membrane oxygenation (ECMO) patients. These patients often have multiorgan failure, so this should be considered during the decision-making process. Patients generally need mechanical support because they lack oxygen delivery to their tissues. Dr Klompas notes that laboratory professionals are ideally suited to help clinicians understand and contextualize responses among patients.