NEW YORK (Reuters Health) – Women with polycystic ovary syndrome have increased levels of LDL-cholesterol and non-HDL-cholesterol, as well as more widely recognized alterations in triglycerides and HDL cholesterol, according to the results of a meta-analysis of cross-sectional studies.

“We recommend that all women with PCOS be screened for dyslipidemia, including LDL-cholesterol and non-HDL-cholesterol determinations, for effective cardiovascular risk prevention,” Dr. Enrico Carmina, of the University of Palermo, Italy, and colleagues write in the January 17 online issue of Fertility and Sterility.

The authors conducted a meta-analysis of 24 studies comparing lipid levels in women with and without PCOS. They found, as expected, that triglyceride levels were 26 mg/dL higher and HDL-cholesterol concentrations were 6 mg/dL lower in women with PCOS.

Also, the researchers report, “LDL-cholesterol and non-HDL-cholesterol concentrations were higher in PCOS: by 12 mg/dL and 19 mg/dL, respectively.”

Even when the data were matched on BMI, differences in LDL-cholesterol and non-HDL-cholesterol were still 9 mg/dL and 16 mg/dL, respectively, according to the report.

Dr. Carmina and colleagues conclude that PCOS is characterized not only by low HDL-cholesterol and increased triglycerides but also by increased LDL-cholesterol and non-HDL-cholesterol.

The authors point out that atherosclerotic processes start early in life, so it’s important to assess and eventually treat altered lipid values in young women with PCOS. They advise: “In prevention of cardiovascular risk, the first goal is to bring LDL-C to normal levels by using lifestyle intervention and medication if necessary. The second goal is keeping non-HDL-C reduced.”

Reference:

Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis


Fertil Steril 2011.